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Some events may have been due to an Methocarbamol generic For Order rapid rate of Methocarbamol generic For Order injection. Body as a whole: Anaphylactic reaction, angioneurotic edema, headache In most cases of syncope there was spontaneous recovery. Dyspepsia, jaundice including cholestatic jaundice, nausea and vomiting Hemic and lymphatic system: Hypersensitivity reactions Nervous system: The psychic trauma of the procedure may have been a contributing factor. Skin and special senses: Methocarbamol may inhibit the effect of pyridostigmine bromide. Therefore, methocarbamol should be used with caution in patients with myasthenia gravis receiving anticholinesterase agents.

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There have been Methocarbamol generic For Order rare reports of fetal and congenital abnormalities following in utero exposure to methocarbamol. Patients should be cautioned about operating machinery, including automobiles, until they are reasonably certain that methocarbamol therapy does not adversely affect their ability to engage in such activities. Rate of injection should not exceed 3 mL per minute—i. A Methocarbamol generic For Order position will reduce the likelihood of side reactions. Blood aspirated into the syringe does not mix with the hypertonic solution. This phenomenon occurs with many other intravenous preparations.

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The blood may be injected with the methocarbamol, or the injection may be stopped when the plunger reaches the blood, whichever the physician prefers. The Methocarbamol generic For Order dosage should not exceed 30 mL three vials a day for Methocarbamol generic For Order than three consecutive days except in the treatment of tetanus. Caution should be observed in using the injectable form in patients with suspected or known seizure disorders. Carcinogenesis, Mutagenesis, Impairment Of Fertility Long-term studies to evaluate the carcinogenic potential of methocarbamol have not been performed.

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Overdose of methocarbamol is frequently in conjunction with alcohol or other CNS depressants and includes the following symptoms: Treatment Management of overdose includes symptomatic and supportive treatment. The usefulness of hemodialysis in managing overdose is Methocarbamol generic For Order. This caution is necessary because of the presence of polyethylene glycol 300 in the vehicle. A much larger amount of polyethylene glycol 300 than is present in recommended doses of ROBAXIN Injectable is known to have increased pre-existing acidosis and urea retention in patients with renal impairment.

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Although the amount present in this preparation is well Methocarbamol generic For Order the limits of safety, caution dictates this contraindication, Methocarbamol Generic For Order. It has no direct action on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber. Pharmacokinetics In healthy volunteers, the plasma clearance of methocarbamol ranges between 0. Methocarbamol is metabolized via dealkylation and hydroxylation.

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Conjugation of methocarbamol also is likely. Essentially all methocarbamol metabolites are eliminated in the urine. Small amounts of unchanged methocarbamol also are excreted in the urine.

Because methocarbamol may possess a general CNS-depressant effect, patients should be cautioned about combined effects with alcohol and other CNS depressants.

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